Mechanistic Studies of Catalytic Direct Arylation Reactions of Heteroaromatics using Mass Spectrometry.

• Grant number: 10/00257-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2010
• End date: February 28, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Marcos Nogueira Eberlin
• Grantee: Marla Narciso Godoi
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This project seeks to evaluate the use of ESI-MS-MS Mass Spectrometry methodology for the validation of mechanistic proposals in the literature for catalytic direct arylation. This novel approach could potentially identify reaction intermediates not observable by conventional techniques. The detailed mechanistic information obtained will either support or refine the current undertanding.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GODOI, MARLA N.; DE AZAMBUJA, FRANCISCO; MARTINEZ, PABLO DAVID G.; MORGON, NELSON H.; SANTOS, VANESSA G.; REGIANI, THAIS; LESAGE, DENIS; DOSSMANN, HELOISE; COLE, RICHARD B.; EBERLIN, MARCOS N.; et al. Revisiting the Intermolecular Fujiwara Hydroarylation of Alkynes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2017, n. 13, p. 1794-1803, APR 3 2017. (10/00257-3, 08/00122-0, 10/11068-7, 11/23832-6)