Effects of pre-anesthetic medication acepromazine associated with nalbuphine, morphine or butorphanol upon anesthetic induction dose of propofol and cardiopulmonary evaluation in dogs

• Grant number: 09/00619-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2009
• End date: April 30, 2010
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Celina Tie Nishimori Duque
• Grantee: Gabriel Fernando Müller Santos
• Host Institution: Coordenadoria Adjunta de Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

The anesthetic practices using pre-anesthetic medications aim to minimize several side effects that may occur employing some anesthetic agents, and reduce anesthetic requirement during the procedure. Furthermore, it is possible to obtain pain suppression, tranquilization of the animal and promote smoothly and calmly anesthetic induction and recovery.Anesthetic protocols using propofol are commonly used because this drug allows fast and calm anesthetic induction and recovery, mainly when associated with a preanesthetic medication. Due to absent of cumulative effects, this drug can be administered repeatedly.Thereby, it is known that morphine is a great potency analgesic opioid used to control severe pain. However, it has strong side effects, as respiratory depression and vomit. Nalbuphine is an agonist- antagonist opioid that has, as butorphanol, ceiling effect and side effects as respiratory depression, but less intense than agonist opioids promote. Moreover, butorphanol and nalbuphine can be used to reverse these side effects. However, when opioid is associated with a tranquilizer, as acepromazine, there is effective and safe sedation.Nevertheless, studies that evaluate the effects of the association between acepromazine and butorphanol or acepromazine and nalbuphine as pre-anaesthetic medication or on the induction dose of propofol are very scarce. Therefore, it was considered relevant to evaluate cardiorespiratory effects of association of acepromazine with nalbuphine, butorphanol or morphine, as preanaesthetic medication in dogs induced to propofol anesthesia, as well as verify drugs influence upon induction dose of propofol.