ADIPOSE TISSUE AND BONE: METABOLIC PATHWAY BETWEEN VITAMIN D AND VITAMIN D RECEPTOR (VDR), OSTECALCIN AND LEPTIN GENOTIPES IN METABOLIC SYNDROME INDIVIDUALS FROM LONGITUDINAL HEALTH STUDY (ELSA).

• Grant number: 10/08386-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2010
• End date: October 31, 2011
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Lígia Araújo Martini
• Grantee: Carlos Eduardo Andrade Chagas
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Metabolic Syndrome (MS), the clinical condition where there are diverse cardiovascular and metabolic abnormalities such as obesity, insulin resistance, dyslipidemia and hypertension, is currently the main cause of cardiovascular disorders in the world. In Brazil, the prevalence of MS-related conditions, especially obesity, has increased dramatically. Recently, there are considerable interest onthe interaction between adipose tissue and the bone. From a series of in vitro studies, it was described an elegant mechanism linking adipose tissue and the bone that involves factors (osteocalcin, leptin and adiponectin) secreted by both cells types. It is suggested that something similar could occur in humans, which would allow the establishment of therapeutic strategies to improve the bone focusing on the adipocyte and / or vice versa. The regulation of bone metabolism by vitamin D (VD) is classically known. However, more recently, it was described that subjects with MS presented abnormal VD homeostasis and that VD serum concentration was positively associated with adiponectin and negatively correlated with leptin. Furthermore, the expression of osteocalcin is regulated by VD through the interaction with its nuclear receptor (VDR). Thus, the present project presents the hypothesis that the interaction between adipose tissue and the bone occur according to the VD-VDR pathway status. It is also speculated that besides the serum VD and VDR genotype, both serum concentration and genotype of OCN and leptin and Lepr genotype may also be involved and could represent others important biomarkers to identify people at high risk of MS. We intend to test this hypothesis in subjects with and without MS who live in São Paulo.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDRADE CHAGAS, CARLOS EDUARDO; BORGES, MARIA CAROLINA; MARTINI, LGIA ARAUJO; ROGERO, MARCELO MACEDO. Focus on Vitamin D, Inflammation and Type 2 Diabetes. NUTRIENTS, v. 4, n. 1, p. 52-67, JAN 2012. (10/08386-7)