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Modulation of PI3-K/AKT pathway by renin-angiotensin system inhibition in obesity experimental model

Grant number: 09/15960-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2010
Effective date (End): December 31, 2010
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Aparecida Emiko Hirata
Grantee:Marina Lúcia Bulla
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Insulin plays a central role in the regulation of glucose homeostasis and acts in a coordinated cellular events that regulate the metabolic and growth, so when we consider situations of insulin resistance, we must do not take into account only the metabolism of glucose. Insulin resistance is considered the main pathophysiological feature of metabolic syndrome that is defined by a set of abnormalities including glucose intolerance, hypertension, abdominal obesity and dyslipidemia. It is known that insulin is a hormone with powerful metabolic effects that are dependent on several signaling pathways specific and strictly regulated. The Angiotensin II, for example, has attracted great interest due to the significant clinical association between type 2 diabetes mellitus and hypertension. Several studies show that intracellular signaling systems of Ins and Angio II are connected and influence each other.Define the steps in insulin signaling and resistance is a challenge to biochemical research may result in the development of new treatments for patients suffering from this pathogenesis.