Design of experiments and optimization of operating conditions in a simulated moving bed: application in chiral drugs separation

• Grant number: 06/02511-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2006
• End date: August 31, 2007
• Field of knowledge: Engineering - Chemical Engineering
• Principal Investigator: Cesar Costapinto Santana
• Grantee: Amaro Gomes Barreto Júnior
• Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The continuous chromatography with simulated moving bed (SMB) technology has been used with increasing success for the separation of binary mixtures of high valued compounds. The combination of this technology with high capacity and high selectivity stationary phases turns the SMB a highly competitive process, including for commercial purposes. Due to the complex design of these SMB units, is necessary to use a mathematical characterization of the dynamical behavior for the multiple column chromatographic process, as well as the optimization of the operating conditions through numerical simulations. This proposal is concerned with the sequential design of experiments aiming at the thermodynamics and mass transfer mechanisms as well as the application of stationary and dynamics optimization techniques for the design of operational conditions. The described methodologies are going to be used for applications of the anesthetic bupivacaine, the antidepressant rolipram and the anti-cancer compound mitotane.The stationary phase used is Kromasil® CHI TBB in all the cases. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARRETO, JR., AMARO GOMES; DA SILVA, JR., IVANILDO JOSE; GARCIA DOS SANTOS, MARCO ANTONIO; DE VEREDAS, VINICIUS; SANTANA, CESAR COSTAPINTO. Modeling, Simulation, and Experimental Evaluation of Continuous Chromatographic Separation of Ketamine Enantiomers on MCTA. Journal of Liquid Chromatography & Related Technologies, v. 31, n. 20, p. 3057-3076, 2008. (06/02511-9)