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Evaluation of NFkB and PPAR-gama transcription factors expression and production of IL-1, IL-3, IL-6, TNF-alfa, GM-CSF, SCF in mesenchymal progenitor cells from wistar rats submitted to a hyperlipidic diet

Grant number: 10/14981-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2010
Effective date (End): October 31, 2011
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Ricardo Ambrósio Fock
Grantee:Mayara Cortez
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The obesity represents a serious public health problem that affects both developement and developed countries, and is common associated with chronic inflammation which predisposes to insulin resistance and development of diabetes mellitus type 2, implying an increased risk for cardiovascular disease.The hematopoietic tissue has a high proliferation rate and cell turnover and high demand for nutrients. The hematopoietics tissues have the capacity to increase production and accelerate cellular maturation of one or more populations of cells as a mechanism to adapt to physiological or pathological conditions.Obesity is associated with increased levels of leptin having a direct and significant effect on cell proliferation in early stages of hematopoietic development and can stimulate the differentiation of myeloid and erythroid lineages. The balance control between self-renewal, proliferation, survival, maturation and differentiation of stem cells is the result of multiple regulatory processes involving cell-cell interactions and hematopoietic growth factors. Knowing that obesity itself can generate several mediators which could influence the complex regulation of hematopoiesis, it is proposed, in this study, to evaluate the obesity effects on transcription factors expression involved in mesenchymal cell differentiation.