Synthetic glycopeptide substrates for Trypanosoma cruzi trans-sialidase

• Grant number: 00/06522-9
• Support Opportunities: Scholarships abroad - Research
• Start date: October 08, 2000
• End date: April 07, 2001
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Ivone Carvalho
• Grantee: Ivone Carvalho
• Host Investigator: Robert A. Field
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: University of East Anglia (UEA), England

Abstract

The trans-sialidase from Trypanosoma cruzi is involved in parasite invasion and defense. This project will involve the synthesis of substrate analogues to aid structure-function studies with a view to developing therapeutic ligands. Progress will be helped significantly by a collaborative approach involving Professor Rob Field (carbohydrate chemistry and enzymology, St Andrews), Professor Sérgio Schenkman (biochemistry and microbiology, Sao Paulo) and Professor Garry Taylor (protein crystallography, St. Andrews) which brings together complementarity of techniques and a breadth expertise. (AU)