Ambient air particles increase cardiac vulnerability to ischemia

• Grant number: 99/02116-7
• Support Opportunities: Scholarships abroad - Research
• Start date: November 18, 1999
• End date: November 17, 2000
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Paulo Hilário Nascimento Saldiva
• Grantee: Paulo Hilário Nascimento Saldiva
• Host Investigator: John J. Godleski
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: Harvard University, Cambridge, United States

Abstract

Research conducted will address the following specific aims: To investigate through toxicological studies the interactions between particulate matter and gaseous copollutants in producing harmful short-term adverse health effects. To determinate through toxicological studies the most biologically importante physical and chemical characteristics and constituents of particulate matter that produce adverse health effects. To define the most biologically important constituents and characteristics of particulate matter that might adversely affect health, especially for potentially susceptible subpopulations. To define the biological mechanisms by which cardiac effects occur. (AU)