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Predictive validity of methods for caries lesions activity assessment

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Author(s):
Isabela Floriano Nunes Martins
Total Authors: 1
Document type: Master's Dissertation
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO)
Defense date:
Examining board members:
Mariana Minatel Braga Fraga; Fausto Medeiros Mendes; Lucia de Fátima Almeida de Deus Moura
Advisor: Mariana Minatel Braga Fraga
Abstract

Carious lesions activity assessment has been used in determining the caries prognosis and in the treatment decision process. For activity status classification, some visual criteria have been proposed as the Nyvad\'s system and the International Caries Detection and Assessment System in conjunction with the Lesion Activity Assessment (ICDAS+LAA). Differences have been shown in determining the activity by these two indices, but using the criterion validation with methyl red dye, whose use is no consensus in the literature. This study aimed to perform the predictive validation of Nyvad\'s system and ICDAS+LAA, as well as some clinical characteristics used in the caries activity assessment when applied separately and combined. We also seek the association of independent variables related to the tooth and the child with the caries progression. For this, the occlusal surfaces of primary molars of 208 children were examined using the indices above. Explanatory variables related to the tooth and the child were also collected. A reference examiner conducted the examination of the same sites for evaluation of clinical features related to carious lesions activity: potential for plaque stagnation, staining, opacity, cavitation, texture and depth. One year after the first examination, 151 children were evaluated by the same examiners, following the same visual criteria, however, only for severity assessment. A total of 845 occlusal surfaces were reassessed. For predictive validation, lesion progression was used as outcome, as the occurrence of dentine cavitation, surface restoration or extraction of the tooth. Individual regression analyzes were performed to each index to investigate the association between the outcome and activity status determined by the index (sound, active and inactive lesions) and some characteristics of teeth and children. Regression analyzes were also performed to investigate the association between the lesions progression and the clinical parameters, individually or combined. We used Poisson regression analysis to test univariate and multivariate models, when appropriate. The relative risk for each condition tested was calculated considering a confidence interval of 95% (95% CI). The active and inactive lesions classified by Nyvad\' system and ICDAS+LAA showed no difference in caries lesions progression after one year. However, during this period, the lesions severity was associated with their progression. Cavitated or dentine lesions had a higher risk of progression compared to sound or non-cavitated surfaces, and other parameters as texture and opacity did not influence the prediction of progression of cavitated lesions. For non-cavitated lesions, roughness and opacity seems to be a characteristic that may help to distinguish lesions that tend to have higher risk of progressing. After one year, the activity status classified by any index is not associated with greater progression of lesions, whereas the severity, a simplest parameter to be assessed, showed association. To cavitated lesions, other features related to the caries lesions activity status have a little contribution in predicting the lesions progression. Roughness and staining may be useful parameters to assist the prediction of non-cavitated lesions progression. (AU)

FAPESP's process: 11/16415-0 - Concurrent and predictive validity of two visual indices for caries lesion activity assessment in primary teeth
Grantee:Isabela Floriano Nunes Martins
Support Opportunities: Scholarships in Brazil - Master