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Immunomodulation of experimental autoimmune encephalomyelitis by salivary gland extract of Aedes aegypti.

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Author(s):
Anderson Daniel Ramos
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas
Defense date:
Examining board members:
Anderson de Sá Nunes; Alessandro dos Santos Farias; Joilson de Oliveira Martins; Vania Luiza Deperon Bonato Martins; José Marcos Chaves Ribeiro
Advisor: Anderson de Sá Nunes
Abstract

The saliva of hematophagous insects has molecules that can modulate the host immune system. Based on the literature about activities found in Aedes aegypti saliva, we investigate if SGE of this species could modulate EAE. We have immunized C57BL/6 mice with MOG35-55, and carried out a treatment with SGE. The treatment with SGE reduced the incidence of disease and caused a delay onset of clinical signs making them softer. We have observed that modulation occured in the induction phase of immune response, not in effector phase. In fact, SGE can suppress the disease by four ways: 1) decreasing the expression of MHCII, CD80 and CD86 in dendritic cells and decreasing the production of cytokines responsible for Th1/Th17 response induction; 2) inducing cells producing IL-10 in vivo; 3) inducing apopotosis in naive T lymphocytes; 4) inducing cells Th2 producing IL-4 e IL-5. We came to the conclusion that SGE can act in supressing symptoms during the course of EAE and inhibiting the beggining of autoimmune response. (AU)

FAPESP's process: 11/22669-4 - Immunomodulation of experimental autoimmune encephalomyelitis by salivary gland extract of Aedes aegypti
Grantee:Anderson Daniel Ramos
Support type: Scholarships in Brazil - Doctorate