Role of P2X7 receptor in modulation of lung immune response induced by hypervirulent mycobacteria.

Author(s)

Caio César Barbosa Bomfim

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2015-02-09

Examining board members

Maria Regina D'Imperio Lima; José Carlos Farias Alves Filho; Alessandra Pontillo

• Advisor: Maria Regina D'Imperio Lima

Abstract

Tuberculosis (TB) is infectious diseases caused by Mycobacterium tuberculosis (Mtb) that mainly affect the respiratory system. Beijing 1471 strain (Mtb) induce a strong pro-inflammatory response, while MP287/03 strain (M. bovis) induce a weak pro-inflammatory response. The P2X7 receptor (P2X7R) is a sensor of extracellular ATP, a damage-associated molecule that is released from necrotic cells and that induces pro-inflammatory cytokine. TB caused by both hypervirulent strains Beijing 1471 and MP287/03 is attenuated in P2X7R deficient mice (P2X7RKO). Therefore, our aim was to investigate the role of P2X7R in imune response of TB induced by MP287/03 and Beijing 1471 strains. We has note that despite Beijing 1471 and MP287/03 strains have opposite immunomodulatory properties, the P2X7R have an important role in modulating the immune response induced by both strains. Thus, the lung immune responses induced by both hypervirulent infections in the absence of this receptor were similar to that induced by less virulent H37Rv Mtb mycobacteria. (AU)

• FAPESP's process: 12/22587-0 - Role of P2X7 receptor in modulation of lung immune response induced by hypervirulent mycobacteria
• Grantee: Caio César Barbosa Bomfim
• Support Opportunities: Scholarships in Brazil - Master