Analysis of the frequency of the polimorphisms in IL28B and IL28R1 genes in patients affected by meningiomas

Author(s)

Aline Faria Galvani

• Document type: Master's Dissertation
• Press: Botucatu. 2016-02-05.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu
• Defense date: 2015-08-20
• Advisor: Maria Inês de Moura Campos Pardini; Adriana Camargo Ferrasi

Abstract

Meningiomas are the most common tumors of the central nervous system, despite being benign and grow slowly, can recur in case of incomplete surgical resection. They are classified according to the cells involved and their rate of malignancy. The role of the immune system in preventing the emergence and progression of tumors has been the subject of many studies in the field of tumor immunology. Interferon (IFNs) were originally associated with antiviral response, however, subsequent studies revealed the involvement of these cytokines in the regulation of cell growth and their immunomodulatory effect.Thus, the aim of this study was to analyze the genetic variation frequency of IL28B and IL28R1 in patients with meningioma. Sixty patients treated by UNESP Neurosurgery service of Botucatu/SP were included in this study. Polymorphism rs12979860 C/T analysis showed statistical significance when compared with healthy Brazilian's genotypic frequency. New genetic variation (missense and silent) were detected in IL28B and IL28R1 through reference sequences analysis (NCBI). These data support an important relation of these genetic variations related to protein functions, however other studies of the consequences of these changes in the development and progression of meningiomas should be considered (AU)

• FAPESP's process: 13/21586-3 - Analysis of polymorphismsfrequency of IL28B and IL28R1 genes and profile of SOCS1 methylation in patients affected by meningioma
• Grantee: Aline Faria Galvani
• Support Opportunities: Scholarships in Brazil - Master