Full text
| |
| Author(s): |
Maria Emilia Zenteno
Total Authors: 1
|
| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2015-11-12 |
| Examining board members: |
Joao Gustavo Pessini Amarante Mendes;
Alexandre de Castro Keller;
Jean Pierre Schatzmann Peron;
Daniela Santoro Rosa;
Alexandre Alarcon Steiner
|
| Advisor: | Joao Gustavo Pessini Amarante Mendes |
| Abstract | |
CD4+ T lymphocytes (LTCD4+) suffer cell death by a process known as activation-induced cell death (AICD) at the end of immune response. Previous results from our group showed that melatonin can inhibits AICD process in LTCD4 at in vitro experiments. Therefore, the aim of this work is verify if a melatonin can act as immune stimulator increasing a LTCD4-mediated immune response in vivo. We showed that 3 and 9 mg/Kg of exogenous melatonin added during immunization resulted in potentiation dose-dependent of Delayed-type hypersensitivity (DTH) response. The treatment with melatonin increased the absolute number LTCD4 antigen-specific, probably by increment of its proliferation. In experiment of T cell differentiation, we observed that the treatment with melatonin stimulated LTCD4 production of Th1 and Th2 profile however blocked the Th17 lymphocytes production. In conclusion, our results support the idea about a regulator role of melatonin on LTCD4 lymphocytes function for development of an immune response. (AU) | |
| FAPESP's process: | 11/06178-0 - Effect of regulation of FASL by Melatonin in CD4 T lymphocytes |
| Grantee: | Maria Emilia Zenteno |
| Support Opportunities: | Scholarships in Brazil - Doctorate |