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| Author(s): |
Luciana Paroneto Medina
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2015-11-18 |
| Examining board members: |
Joao Gustavo Pessini Amarante Mendes;
Maristela Martins de Camargo;
Veronica Porto Carreiro de Vasconcellos Coelho;
Jean Pierre Schatzmann Peron;
Frederico Azevedo da Costa Pinto
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| Advisor: | Joao Gustavo Pessini Amarante Mendes; Alexandre Salgado Basso |
| Abstract | |
Results obtained by our group demonstrated in vitro that PGE2 is able to modulate CD4+ T cells survival protecting these cells from death. Within the EAE model, we hypothesized that PGE2 released by APCs during the induction phase, modulate survival of autoreactive specific lymphocytes by induction the disease. We carried out the treatment of EAE in mice subjected to indomethacin for 5 days and noticed that there is reduction of EAE associated with decreased IFN-γ, IL-17 and GM-CSF producing T cells, and infiltrating macrophages and activated microglia in the CNS. The results suggest that indomethacin reduces EAE and its antigen-specif response demonstrating their importance in the modulation of T lymphocyte responses in autoimmunity. (AU) | |
| FAPESP's process: | 11/06177-4 - Investigating of the relationship between the modulation of FASL expression by PGE2 and CD4+ T lymphocytes survival |
| Grantee: | Luciana Paroneto Medina |
| Support Opportunities: | Scholarships in Brazil - Doctorate |