Protein synthesis and degradation pathways in insulin resistance induced by high fat diet: The effect of omega-3 fatty acid supplementation and aerobic exercise training.

Author(s)

Luis Gustavo Oliveira de Sousa

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2015-10-19

Examining board members

Sandro Massao Hirabara; Guilherme Giannini Artioli; Renata Gorjão; Rafael Herling Lambertucci; Anselmo Sigari Moriscot

• Advisor: Sandro Massao Hirabara

Abstract

There is a worldwide increase in the incidence of obesity that is associated with significant increases in medical costs. In the United States alone, treatment of obesity related health problems accounts for up to 9% of the total annual cost of healthcare, an estimated $147 billion per year. The effects of obesity on skeletal muscle are correlated with insulin resistance (IR), diabetes and decreased of quality of life. Recent work has demonstrated that a high fat diet (HFD) decreases the ability of skeletal muscle to hypertrophy in a model of increased mechanical load. This negative effect on muscle growth is correlated with a decrease in activation of the Akt/mTOR signaling pathway and an increase in endoplasmic reticulum stress. (AU)

• FAPESP's process: 10/18921-7 - Pathways of protein synthesis and degradation in the insulin resistance induced by hyperlipidic diet: effect of the omega-3 fatty acid supplementation and aerobic exercise training
• Grantee: Luís Gustavo Oliveira de Sousa
• Support Opportunities: Scholarships in Brazil - Doctorate