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Effect of supplementation with omega-3 fatty acids, with or without practicing regular exercise, in insulin resistance and inflammation in mice subjected to a high fat diet

Grant number: 14/06281-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2014
Effective date (End): December 31, 2014
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Sandro Massao Hirabara
Grantee:Érika Fernandes de Jesus
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Obesity is a major public health problem in both developed countries and in developing countries or poor. In Brazil about 40 % of the population is overweight and obesity is higher in females than in males. Obesity is an etiologic factor in chronic inflammation and consequently the organ dysfunction. Fatty acids have long chain carboxylic acids and, in general, all contain an even number of carbon atoms. The AG family w -3 can be obtained through the diet or produced by the body from linoleic acid and alpha - linolenic acid. The intake of oleic and linoleic fatty acids may increase the release of TNF- a, and the proinflammatory effects accompanying the rapid uptake and metabolism in tissues. In addition, oral supplementation with either GA w -3 fish oil in healthy individuals decreases the production of IL- 1, IL- 2 and IL- 6 and TNF- a in monocytes isolated pro-inflammatory cytokines. Aerobic exercise of mild to moderate intensity has been recommended as a therapy to prevent and treat cardiovascular and related metabolic diseases such as type 2 diabetes mellitus and obesity. These exercises cause several beneficial effects. This project aims to investigate whether supplementation of n-3 FA associated with moderate aerobic exercise can prevent or reduce the deleterious effects of high fat diet in C57BL / 6 mice. (AU)