Effects of thyroid hormone T3 in the central nervous system associated with diabetes mellitus induced by alloxan.

Author(s)

Fernanda Prieto de Almeida

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2016-03-23

Examining board members

Andréa da Silva Torrão; Adriano Namo Cury; Rosangela Aparecida dos Santos Eichler

• Advisor: Andréa da Silva Torrão

Abstract

Neurodegenerative diseases has been related to changes in glucose metabolism and deficiency and /or resistance to brain insulin. In this respect, there appears to be a modulation of thyroid hormones (TH) on insulin signaling and function of the central nervous system (CNS). The objective of this study was to analyze the relationship between hyperthyroidism and the CNS associated with DM. For this, Wistar adult rats were injected with alloxan monohydrate or treated with vehicle and T3 for 30 days and evaluated in behavioral tests and subsequent analyzes of protein in the cortex and hippocampus regions. Chronic treatment with T3 produced an anxiolytic effect and a delay in the acquisition of information, although consolidation not be modified. Furthermore, T3 allowed improvement of the neurodegenerative process and pathway of insulin signaling in the hippocampus of diabetic rats. These data suggest, in general, a beneficial effect of TH on the brain function of the diabetic animals. (AU)

• FAPESP's process: 14/15966-0 - The role of BDNF in the central nervous system associated with hyperthyroidism and diabetes mellitus
• Grantee: Fernanda Prieto de Almeida
• Support Opportunities: Scholarships in Brazil - Master