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| Author(s): |
Karla Lucía Alvarez Fernández
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2016-05-04 |
| Examining board members: |
Ana Paula Lepique;
Antonio Condino Neto;
Alessandra Pontillo;
Luiz Fernando Lima Reis;
João Santana da Silva
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| Advisor: | Ana Paula Lepique |
| Abstract | |
The natural history of cervical cancer begins with a human papilloma virus (HPV) infection of the cells of the basal layer of the epithelium. Persistent infection by high risk HPVs can originate precancerous lesions that may progress to invasive cancer. It has been established the role of the infiltrated inflammatory cells on the progression of the disease. In this work, the phenotype and the frequency of T lymphocytes, macrophages and neutrophils were characterized both in precursor lesions as in invasive carcinoma. In order to stablish a possible relation between the characterized cells, we made a correlation analysis. On the other hand, trying to determine the systemic effect of the tumor we evaluated the frequency of circulating monocyte subtypes and the capacity of dendritic cells to stimulate allogeneic T cells. The data presented will help to understand the role of the immune system cells on the progression of the disease. (AU) | |
| FAPESP's process: | 11/20499-4 - Characterization of the inflammatory responses in human papillomavirus associated cervical lesions |
| Grantee: | Karla Lucía Alvarez Fernández |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |