Sequential effects of aerobic training on the plasma and cardiac renin angiotensin system in SHR. Analysis of oxidative stress, inflammatory profile and cardiac remodeling.

Author(s)

Sebastião Donato Silva Júnior

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2016-07-08

Examining board members

Lisete Compagno Michelini; Dulce Elena Casarini; Maria Luiza Morais Barreto de Chaves; Fabiana de Sant'Anna Evangelista; Julio Cesar Batista Ferreira

• Advisor: Lisete Compagno Michelini

Abstract

The hypertension is followed by renin angiotensin system hyperactivity (RAS). We have showed in SHR rats that plasma RAS hyperactivity precedes the cardiac RAS hyperactivity. Furthermore the RAS hyperactivity was followed by oxidative stress and inflammation increase as well as left ventricle (LV) collagen deposition in SHR. The aerobic training promoted prompt cardiac and plasma RAS activity reduction. It was followed by oxidative stress normalization and inflammatory reduction. Although we did not observe cardiac hypertrophy change, the collagen deposition was reduced in SHR trained group. We suggest the RAS activity reduction as a determinant condition to the beneficial adaptations occurred in the parameters analyzed. Thus contributing to maintenance of cardiac structures and avoids the deleterious cardiac remodeling in SHR. (AU)

• FAPESP's process: 11/15681-8 - Sequential effects of the aerobic training in modulating the activity of renin angiotensin system in plasma and tissue
• Grantee: Sebastião Donato Silva Júnior
• Support Opportunities: Scholarships in Brazil - Doctorate