| Grant number: | 18/08569-6 |
| Support type: | Regular Research Grants |
| Duration: | February 01, 2019 - April 30, 2021 |
| Field of knowledge: | Health Sciences - Physiotherapy and Occupational Therapy |
| Principal researcher: | Hugo Celso Dutra de Souza |
| Grantee: | Hugo Celso Dutra de Souza |
| Home Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
Abstract
We will investigate women in reproductive age and after physiological menopause the effects on hemodynamics, cardiac morphofunctionality, cardiovascular autonomic control, inflammatory markers, and oxidative stress due drug (Enalapril Maleate and Losartan) treatment with different action mechanisms on renin-angiotensin aldosterone system (RAAS). We will also investigate whether the association of aerobic physical training with Enalapril Maleate or Losartan presents different results on the parameters evaluated. Methods: 80 sedentary hypertensive women will be divided into two large groups; (30-45 years old, N = 40) and postmenopausal group (55-65 years old, N = 40). Each group will be subdivided into two smaller groups; group treated with Enalapril Maleate (N = 20) and Losartan treated group (N = 20). All of them will be submitted to following experimental procedures in two moments. Before and after the 16-week aerobic physical training period on a motorized treadmill. Echocardiography; anthropometric analysis; assessment of cardiopulmonary capacity through the ergospirometric test; autonomic assessment through the analysis of baroreflex sensitivity and heart rate and blood pressure variability; cytokines (IL6 and IL10), C-reactive protein and TNF-alpha serum levels; and oxidative stress biomarkers (malondialdehyde, reduced glutathione and vitamin E). (AU)