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Study of aerobic physical training association with enalapril maleate and losartan on different cardiovascular parameters in hypertensive women, before and after the menopause

Grant number: 18/08569-6
Support Opportunities:Regular Research Grants
Duration: February 01, 2019 - April 30, 2021
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Hugo Celso Dutra de Souza
Grantee:Hugo Celso Dutra de Souza
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


We will investigate women in reproductive age and after physiological menopause the effects on hemodynamics, cardiac morphofunctionality, cardiovascular autonomic control, inflammatory markers, and oxidative stress due drug (Enalapril Maleate and Losartan) treatment with different action mechanisms on renin-angiotensin aldosterone system (RAAS). We will also investigate whether the association of aerobic physical training with Enalapril Maleate or Losartan presents different results on the parameters evaluated. Methods: 80 sedentary hypertensive women will be divided into two large groups; (30-45 years old, N = 40) and postmenopausal group (55-65 years old, N = 40). Each group will be subdivided into two smaller groups; group treated with Enalapril Maleate (N = 20) and Losartan treated group (N = 20). All of them will be submitted to following experimental procedures in two moments. Before and after the 16-week aerobic physical training period on a motorized treadmill. Echocardiography; anthropometric analysis; assessment of cardiopulmonary capacity through the ergospirometric test; autonomic assessment through the analysis of baroreflex sensitivity and heart rate and blood pressure variability; cytokines (IL6 and IL10), C-reactive protein and TNF-alpha serum levels; and oxidative stress biomarkers (malondialdehyde, reduced glutathione and vitamin E). (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PHILBOIS, STELLA V.; FACIOLI, TABATA P.; GASTALDI, ADA C.; RODRIGUES, JHENNYFER A. L.; TANK, JENS; FARES, THAUANE H.; RODRIGUES, KARINE P.; SOUZA, HUGO C. D.. Important differences between hypertensive middle-aged women and men in cardiovascular autonomic control-a critical appraisal. BIOLOGY OF SEX DIFFERENCES, v. 12, n. 1, . (18/17892-5, 18/08569-6)
FACIOLI, TABATA DE PAULA; PHILBOIS, STELLA VIEIRA; AGUILAR, BRUNO AUGUSTO; VEIGA, ANA CATARINE; DUTRA DE SOUZA, HUGO CELSO. Combined effects of angiotensin receptor blocker use and physical training in hypertensive men. CLINICAL AND EXPERIMENTAL HYPERTENSION, v. 44, n. 4, p. 10-pg., . (18/08569-6)
HUGO CELSO DUTRA DE SOUZA; STELLA VIEIRA PHILBOIS; TÁBATA DE PAULA FACIOLI; RUI ALBERTO FERRIANI; ADA CLARICE GASTALDI. Aerobic physical training impact on adipokines in women with polycystic ovary syndrome – Effects of body fat percentage. ARCHIVES OF ENDOCRINOLOGY METABOLISM, . (18/08569-6)
PHILBOIS, STELLA V. V.; RIBEIRO, VICTOR B. B.; TANK, JENS; DOS REIS, ROSANA MARIA; GERLACH, DARIUS A. A.; SOUZA, HUGO C. D.. Cardiovascular autonomic modulation differences between moderate-intensity continuous and high-intensity interval aerobic training in women with PCOS: A randomized trial. FRONTIERS IN ENDOCRINOLOGY, v. 13, p. 12-pg., . (18/08569-6, 18/17892-5, 15/14031-0)
SOUZA, HUGO CELSO DUTRA DE; PHILBOIS, STELLA VIEIRA; FACIOLI, TABATA DE PAULA; FERRIANI, RUI ALBERTO; GASTALDI, ADA CLARICE. Aerobic physical training impact on adipokines in women with polycystic ovary syndrome-Effects of body fat percentage. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 66, n. 6, p. 11-pg., . (18/08569-6)

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