The cardioprotective effect of thyroid hormone in ischemia reperfusion experimental model: role of renin angiotensin system.

Author(s)

Ivson Bezerra da Silva

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2016-05-20

Examining board members

Maria Luiza Morais Barreto de Chaves; Vagner Roberto Antunes; Denise de Castro Fernandes; Joel Claudio Heimann; Paulo José Ferreira Tucci

• Advisor: Maria Luiza Morais Barreto de Chaves; Julio Cesar Batista Ferreira

Abstract

Some authors have shown a close relationship between the action of thyroid hormone (TH) on cardiovascular system and renin angiotensin system (RAS) activation. Have been shown that ischemia/reperfusion (I/R) promotes decrease on angiotensin II type 2 receptor (AT2) expression in the myocardium, with functional worsening, on the other hand the AT2R increased improves the cardiac function after ischemia episodes. So, we have hypothesized that the cardioprotective effect of TH in I/R model may occur with the participation of AT2. This hypothesis was tested using I/R model in isolated hearts AT2 knockout and wild-type mice submitted to high levels of T3 by 14 days. The mitochondrial RAS was evaluated, as well as the nitric oxide (NO) role in post-ischemic recovery. The results show that TH induces cardioprotection through AT2 receptor, some mitochondrial metabolism parameters were modulated by TH and the NO production was increased. (AU)

• FAPESP's process: 13/04703-6 - Subcellular renin angiotensin system as mediator of the cardioprotective effector of thyroid hormone in ischemia reperfusion model
• Grantee: Ivson Bezerra da Silva
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)