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| Author(s): |
Camila Heitor Campos
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Piracicaba, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba |
| Defense date: | 2015-11-30 |
| Examining board members: |
Renata Cunha Matheus Rodrigues Garcia;
Dalva Cruz Lagana;
Renato Corrêa Viana Casarin;
Flávia Maia Silveira;
Paula Midori Castelo
|
| Advisor: | Renata Cunha Matheus Rodrigues Garcia |
| Abstract | |
Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting the elderly. Symptoms caused by the disease as memory problems and cognitive deficits can lead to a decline of oral health and commitment of orofacial function. This work was carried out in alternate format, divided into two chapters. Chapter 1 aimed to compare the perception of oral health-related quality of life (OHRQoL) collecting data by mild AD patients and by their caregivers, correlating these data to clinical measures of prostheses quality. Chapter 2 aimed to evaluate chewing function of elderly in mild AD compared to a healthy control group, correlating chewing to cognitive state. To do so, elderly wearing removable dentures diagnosed with mild AD (n = 16, mean age = 77.2 ± 5.8 years), a healthy control group (n = 16, mean age = 76.0 ± 4.4 years), matched for gender, age and dental status, and AD patients¿ caregivers (n = 16, mean age = 51.7 ± 11.1) took part in the study. The OHRQoL perception was assessed by using the Geriatric Oral Health Assessment Index (GOHAI) questionnaire, applied to the AD patients and their caregivers to check the consistency of responses between caregiver and patient. The OHRQoL perception of patients and their caregivers were then compared with prostheses¿ quality, evaluated by a trained researcher. Mastication was assessed by masticatory performance (MP) by using the artificial test food Optocal and the fractioning sieving method. Mini-Mental State Examination (MMSE), applied to the volunteers of the control and experimental groups by a trained examiner to measure cognitive state. In Chapter 1, the Wilcoxon test, chi-square, Cronbach's alpha and Spearman correlations were applied to find out correlation between the GOHAI scores of AD patients and their caregivers, as well as the correlation between GOHAI and prostheses quality scores.. In Chapter 2, data relating on MP and MMSE were submitted to the T test and Pearson's correlation. All statistical analyzes were performed using SAS software with 5% significance level. The general GOHAI score between patients and their caregivers was similar (34.38 ± 2.33 vs 32.94 ± 3.45, respectively, P = 0.262), with good Cronbach¿s alpha correlation (0.71). No correlation was found between GOHAI scores and prostheses¿ quality. Regarding masticatory function, patients with mild AD showed MP (P <0.01) and MMSE (P = 0.01) decreased in the control group, and the MP demonstrated moderate negative correlation with the MMSE (r = - 0.696). Thus, this study showed that the QVRSB perception was evaluated similarly by mild AD patients and their caregivers, but no association with the clinical measures of prostheses¿ quality were found. Mild AD was associated with an impaired chewing function (AU) | |
| FAPESP's process: | 13/10200-7 - Chewing function on Alzheimer's Disease |
| Grantee: | Camila Heitor Campos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |