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| Author(s): |
Patricia Oliveira de Lima
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Piracicaba, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba |
| Defense date: | 2014-02-25 |
| Examining board members: |
Fernanda Klein Marcondes;
Christie Ramos Andrade Leite Panissi;
Leonardo Rigoldi Bonjardim;
Luciano Jose Pereira;
Francisco Carlos Groppo
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| Advisor: | Fernanda Klein Marcondes |
| Abstract | |
Oral diseases, stress and menstrual cycle have been related to the production of volatile sulfur compounds (VSC), main gases responsible for halitosis. The aim of this study was to evaluate the relationship between emotional alterations associated with academic activities and production of VSC. The following parameters were determined: stress levels, salivary flow, salivary concentrations of cortisol, secretory IgA (SIgA), total protein and beta-defensin-2 (?-defensin -2), alpha-amylase activity, and the expression of the proteins mucin 5B, 7 and lactoferrin, in the oral cavity. Women, during menstrual phase of the reproductive cycle, and men, enrolled at Piracicaba Dental School, University of Campinas, participated in the study. The data of psychological analysis showed that the stress associated with academic activities varies between years of the course. Women showed higher oral concentrations of VSC and methyl mercaptan (CH3SH), lower salivary flow, higher concentrations of total protein and SIgA and lower salivary expression of mucins 5B and 7 compared to men. Men and women in the third year of undergraduate course presented higher values of VSC, hydrogen sulfide (H2S), alpha-amylase and mucin 5B compared to students in the first year. There was no difference on the oral concentrations of CH3SH and dimethyl sulphide; salivary proteins, SIgA and cortisol concentrations and salivary flow values between the four years of the undergraduate course. Men scholars in the third year of the undergraduate course showed lower salivary concentrations of ?-defensin-2 compared to the first year. Women scholars in the third and fourth years of the undergraduate course presented higher lactoferrin expression compared to students in the first and second years. There was significant correlation between VSC and H2S in both gender. In women, it was observed correlation between stress and VSC and between stress and alpha-amylase. In men, stress and MUC5B presented positive correlation. The results confirm previous data strengthening the stress influence on the VSC production. Moreover, suggest that the proteins beta-defensin-2, mucin 5B and lactoferrin may be involved in the association between stress and VSC production (AU) | |
| FAPESP's process: | 10/01642-8 - Relationship between stress associated with academic activities and volatile sulfur compounds production: involvement of beta-defensin |
| Grantee: | Patricia Oliveira de Lima |
| Support Opportunities: | Scholarships in Brazil - Doctorate |