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| Author(s): |
Paula Mayara Matos Fialho
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas |
| Defense date: | 2016-02-29 |
| Examining board members: |
Carlos Roberto Silveira Corrêa;
Maria Isabel de Moraes Pinto;
João Tadeu Ribeiro Paes;
Marcos Tadeu Nolasco da Silva;
Djalma de Carvalho Moreira Filho
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| Advisor: | Carlos Roberto Silveira Corrêa |
| Abstract | |
Toxocariasis is a zoonotic disease that is present in Brazil and many other countries. It is caused by Toxocara and the involved species are T. canis and T. cati. The disease impact in human health, particularly children, is still being evaluated, although it has already been suggested as a cause of major clinical manifestations. Nevertheless, many data about the frequency measures as related to the impact of toxocariasis on the human health are still unknown. Therefore, toxocariasis is considered a neglected disease. To achieve our goal was conducted the study different methodologies. Initially, a literature review was done in order to know the prevalence of toxocariasis in Brazil. Another Population-based Study, conducted in the city of Campinas, the study population randomly selected, and one prospective cohort study. The results of this thesis are presented in three chapters, corresponding to three articles. In the first, "A Systematic Review of Toxocariasis: A Neglected but High-Prevalence Disease in Brazil", we conducted a systematic review of the literature following PRISMA guidelines. Applying the established criteria, we identified 160 publications and selected 22 articles for further analyses. The prevalence of toxocariasis in various regions of the country ranged from 4.2% to 65.4%. In the second work, "Seroprevalence of Toxocariasis in Children with Urticaria: Population-based Study in Campinas-SP-Brazil" was a cross-sectional population-based study with children 2-12 years old, in the city of Campinas. The presence of urticaria was observed in 38% of participants. The seroprevalence of toxocariasis was 16%. This study confirmed a positive association urticaria with positive serology for Toxocara and a negative independent association with contact with dog and the number of people living in the household. The third article, "Toxocariasis Incidence and Risk Factors in Children of Campinas-SP-Brazil: Cohort study" shows the incidence of toxocariasis in a cohort of children follow-up for a year. The incidence of toxocariasis was 10.4 per 100 child year. The present study demonstrated that asthma was a risk factor for toxocariasis. Is important that the health professionals and the public health system should be aware that toxocariasis is a health problem and it is necessary to establish prevention and control strategies for this infection (AU) | |
| FAPESP's process: | 12/14134-6 - Toxocariasis and clinical manifestations. A population-based study in Campinas, São Paulo. |
| Grantee: | Paula Mayara Matos Fialho |
| Support Opportunities: | Scholarships in Brazil - Doctorate |