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| Author(s): |
Mariana Hayashi Garcia
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2017-06-19 |
| Examining board members: |
Anderson de Sá Nunes;
Beatriz Simonsen Stolf Carboni;
Denise Morais da Fonseca;
Regis Bernardo Brandim Gomes
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| Advisor: | Anderson de Sá Nunes; Mauro Javier Cortez Véliz |
| Abstract | |
Aedes aegypti is an important vector of disease-causing pathogens such as dengue, yellow fever, Chikungunya and Zika fever. The mosquito female takes a blood meal in order to develop the eggs. In this context, a saliva plays a key role, representing the link between the hematophagous arthropod, its vertebrate host and the potential pathogen to be transmitted. During the evolutionary process, these insects developed a salivary cocktail with an arsenal of molecules presenting several immunomodulatory properties in host cells, such as macrophages. As macrophages are also involved in the mechanisms of response against protozoa of the genus Leishmania and leishmaniasis is a zoonotic disease of great relevance in public health, the aim of this work is to evaluate the effect of salivary gland extract (SGE) of A. aegypti in Leishmania infections. Our results showed increased infection, in vivo and in vitro, in the presence of SGE, strongly suggesting that A. aegypti EGS is able to increase infection by Leishmania. (AU) | |
| FAPESP's process: | 15/12703-1 - Effect of Aedes aegypti salivary components in the infection by parasites of the Leishmania genus |
| Grantee: | Mariana Hayashi Garcia |
| Support Opportunities: | Scholarships in Brazil - Master |