Cardiovascular benefits of aerobic exercise training in aging spontaneously hypertensive rats.

Author(s)

Laís Oliveira Dellacqua

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas
• Defense date: 02 jun. 2017

Examining board members

Vagner Roberto Antunes; Jackson Cioni Bittencourt; Kátia de Angelis Lobo D'Avila; Thiago dos Santos Moreira; Edilamar Menezes de Oliveira

• Advisor: Vagner Roberto Antunes

Abstract

Introduction: The hypertension can be aggravated when associated with aging, and the practice of physical exercise is related to an improvement of the hypertensive picture. Methods: Twelve-month-old SHR and WKY rats were divided into two groups: trained (T) and sedentary (S). Results: The performance of WKY and SHR trained animals was higher in the fourth and eighth week. There was no difference in the body weight of the animals. The SBP, DBP and MAP of SHR animals trained for 2 and 8 weeks was lower than that found in sedentary animals of 8 weeks. The HF component was higher in trained animals for 8 weeks compared to sedentary groups. Physical exercise was not able to modify the number of ChAT and TH positive neurons in both SHR and WKY animals. Conclusion: Physical exercise was able to improve treadmill performance, decrease systolic, diastolic and mean blood pressure, improve baroreflex sensitivity and increase the HF component to the heart. (AU)

• FAPESP's process: 12/22368-7 - Evaluation of transcription factors of the hypothalamic-brainstem nuclei and cardiovascular benefits of exercising training in aging SHR
• Grantee: Laís Oliveira Dellacqua
• Support type: Scholarships in Brazil - Doctorate