Analysis of monocyte chemotactic protein-3 (CCL7) in Hyperglycemic pregnant women with urinary incontinence: prospective cohort of pregnancy up to the first year postpartum

Author(s)

Fernanda Piculo

• Document type: Doctoral Thesis
• Press: Botucatu. 2017-04-25.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu
• Defense date: 2017-02-24
• Advisor: Marilza Vieira Cunha Rudge; Débora Cristina Damasceno; Angélica Mércia Pascon Barbosa; Adonis Hijaz

Abstract

The mild gestational hyperglycemia (MGH) and gestational diabetes mellitus (GDM), referred as gestational hyperglycemia in this study, have important consequences for the mother, fetus and newborn. The association between gestational hyperglycemia and urinary incontinence is scarce in the literature. Our academic research group "Diabetes and Pregnancy - Clinical and Experimental", from Botucatu Medical School, UNESP, has studied the translational aspects of gestational hyperglycemia related to urinary incontinence in females and in animal models. The results help to elucidate the pathophysiological mechanisms that lead to female pelvic floor disorders in women with GDM and HGL, but there is need for further research to expand the understanding of the phenomena that result in better care for patients. Whereas monocyte chemotactic protein-3 (CCL7) is an important factor for the recovery mechanism of urinary incontinence, our hypothesis was that patients with GDM or HGL present changes in the CCL7 levels and this would retard/prevent the migration of mesenchymal stem cells to the site of injury caused by IU, causing consequences in the postpartum period. Thus, the purpose of this study was to determine the CCL7 levels profile in hyperglycemic pregnant women with urinary incontinence since the beginning of pregnancy up to the first year postpartum and to examine the correlation between the progression of UI and serum levels of CCL7. This identification may indicate CCL7 as a possible biomarker of recovery UI in hyperglycemic women during pregnancy and in the postpartum period and subsequently establish effective therapeutic intervention with consistent pathophysiological basis. Statistical analysis and the choice by comparing tests between variables and groups were executed respecting the presuppositions determined by the results, characteristics and behavior of the variables. (AU)

• FAPESP's process: 12/25060-3 - Analysis of monocyte chemotactic protein-3 (CCL7) in hyperglycemic pregnant women with urinary incontinence: prospective cohort from pregnancy to six months postpartum
• Grantee: Fernanda Piculo
• Support Opportunities: Scholarships in Brazil - Doctorate