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| Author(s): |
Patrícia Macchiaverni
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-12-07 |
| Examining board members: |
Antonio Condino Neto;
Maria Cristina Roque Antunes Barreira;
Ana Maria Caetano de Faria;
Sonia Jancar Negro;
Maria Notomi Sato
|
| Advisor: | Antonio Condino Neto |
| Abstract | |
Experimental data in rodents indicate that maternal allergen-specific IgG prevents allergic sensitization in the progeny. Airborne allergens in maternal milk also protects breastfeed mice by oral tolerance induction. In this study, we assessed in humans whether Der p and Blo t allergens and specific antibodies were transferred during pregnancy and breastfeeding in a cohort of 91 paired samples of maternal blood, colostrums and umbilical cord blood. Our study indicates that Der p 1 and Blo t 5 can be found in both, cord blood and colostrums, and identifies maternal atopy as a critical factor for increased levels of allergen-specific IgG in these compartments. In the cord blood the biggest difference between atopic and non atopic mothers was observed for IgG4. Der p 1 and Blo t 5 concentrations were not correlated with maternal atopic status nor specific-antibodies levels. In colostrums, only the concentration of Der p 1 was higher in atopic mothers and correlated with colostrums specific-IgG levels. (AU) | |
| FAPESP's process: | 08/51535-3 - Study of maternal antibodies response to D. pteronyssinus, B. tropicalis and T. putrescentiae mites, and their passive transfer through placenta and maternal colostrum |
| Grantee: | Patricia Macchiaverni |
| Support Opportunities: | Scholarships in Brazil - Doctorate |