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| Author(s): |
Juliana Bezerra Medeiros de Lima
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Ribeirão Preto. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) |
| Defense date: | 2018-12-04 |
| Examining board members: |
Jose Antunes Rodrigues;
Eduardo Colombari;
Rita de Cassia Aleixo Tostes Passaglia;
Luis Carlos Reis
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| Advisor: | Jose Antunes Rodrigues |
| Abstract | |
Carbon monoxide plays important roles in animal physiology including synaptic plasticity, learning and memory processes, inflammation and hypothalamic neuropeptide release. Recently it has been demonstrated that the AVP and OT release in response to changes in hydromineral balance can be modulated by this gaseous neuromodulator; however, the mechanisms by which this modulation occurs need to be elucidated. In order to answer this questioning, we evaluated the CO effect on neuroendocrine responses, SON magnocellular neurons passive membrane properties, p38 MAPK signaling, NO/NOS system and astrocytes participation in rats during control or 24/48 WD conditions. We observed that CO formation inhibition reduced the water deprivation-induced increase in plasma AVP and OT concentration and NOS activity in basal and 48 WD groups; while p-p38 MAPK/p38 MAPK ratio was increased by central CO donation in both euhydrated and dehydrated conditions. Furthermore, we demonstrated HO-1, p38 MAPK and p-p38 MAPK expression in MBH astrocytes. These data indicate the CO role as neuromodulatory molecule in neuroendocrine responses to dehydration where it might play its biological functions through p38 MAPK phosphorylation and NOS activity in a water restriction longer period (AU) | |
| FAPESP's process: | 14/10060-3 - Participation of intracellular pathways modulated by carbon monoxide in the regulation of hydroeletrolitic balance |
| Grantee: | Juliana Bezerra Medeiros de Lima |
| Support Opportunities: | Scholarships in Brazil - Doctorate |