Efficacy of ketoprofen in programs for selective treatment of natural clinical mastitis cases

Author(s)

Giulia Soares Latosinski

• Document type: Master's Dissertation
• Press: Botucatu. 2019-06-27.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu
• Defense date: 2019-04-29
• Advisor: José Carlos de Figueiredo Pantoja

Abstract

The objective of this study was to evaluate the efficacy of ketoprofen in culture-negative clinical mastitis (CM) cases. Cows from three commercial herds were randomly allocated into two experimental groups. The ketoprofen group (N = 65 quarters) received a single intramuscular injection of 3 mg/kg of ketoprofen. The control group (N = 64 quarters). Milk samples were collected at the time of CM diagnosis and at 14 (D14) and 21 (D21) days after the case. The outcomes evaluated were clinical cure, relapse and recurrence of CM, risk of new intramammary infection (IIM) at D14 and D21, and somatic cell count at D14 and D21. The proportion of clinical cure, relapse and recurrence of CM in the ketoprofen and control groups was 83.08%, 85.94%, 18.52% and 18,18%, 16,67% and 16,36%, respectively. The relative risk of all mentioned outcomes was not different between the experimental groups. For both analyses, the odds of new IIM were not different between the experimental groups. Mean SCC was not different between sampling days or experimental groups. Results suggest that the use of ketoprofen for culture-negative CM was not associated with the risk of clinical cure, relapse and recurrence of CM, new IIM and SCC. (AU)

• FAPESP's process: 17/20576-5 - Efficacy of ketoprofen in programs for selective treatment of natural clinical mastitis cases
• Grantee: Giulia Soares Latosinski
• Support Opportunities: Scholarships in Brazil - Master