Linoleic fatty acid and wound healing: focus on angiogenesis

Author(s)

Jéssica Rondoni Silva

• Document type: Master's Dissertation
• Press: Limeira, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas
• Defense date: 2019-02-01

Examining board members

Hosana Gomes Rodrigues; Igor Luchini Baptista; Marcelo Bispo de Jesus

• Advisor: Hosana Gomes Rodrigues

Abstract

Wound healing is a physiological process initiated whenever there is a breakdown of any body tissue. It is divided into 3 concomitant phases: inflammation, proliferation and maturation. During the proliferative phase, formation of new blood vessels (angiogenesis) plays a key role, as vessels are essential for the arrival of inflammatory cells, removal of cellular debris and adequate supply of oxygen and nutrients to the injured site. In previous studies, we observed that linoleic acid (LA, 18: 2 'omega'-6) increased the number of new blood vessels in the skin, favoring healing in rats. However, the mechanisms involved in these effects have not been clarified... The abstract is available with the full electronic document (AU)

• FAPESP's process: 16/15955-4 - Effects of linoleic acid on in vitro modulation of angiogenesis process
• Grantee: Jessica Rondoni Silva
• Support Opportunities: Scholarships in Brazil - Master