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| Author(s): |
Carina Calixto Jank
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2014-05-30 |
| Examining board members: |
Luiz Vicente Rizzo;
Sérgio Podgaec;
Karina Inácio Ladislau de Carvalho Salmazi
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| Advisor: | Luiz Vicente Rizzo |
| Abstract | |
Endometriosis (EDT) is a gynecological disease characterized by the presence of endometrial cells out of the uterine cavity, which affects women in reproductive age. We postulated that alterations in the frequencies of regulatory T cells (Treg), natural killer cells (NK), myeloid-derived suppressor cells (MDSC) and dendritic cells (DC) in the peritoneum could justify the reduced capacity of the immune system to react to these ectopic endometrial cells, allowing them to invade distant tissues. Here, Treg, NK, MDSC and DC were quantified in the peritoneal fluid (PF) and peripheral blood (PB) of women with EDT, in order to associate them with the development of EDT; cytokine levels were also assessed. In EDT, higher frequencies of Treg, MDSC and DC in the PB and apparent lower frequencies of these cells in the PF were observed; IL-12 concentration was smaller in PB of EDT compared to control. No differences between groups were observed for NK cells and the other cytokines evaluated. The results indicate higher frequencies of regulatory cells in PB samples of EDT patients, although these findings were not reflected in PF samples. (AU) | |
| FAPESP's process: | 12/17795-3 - Evaluation of regulatory T cells, uterine NK and myeloid-derived suppressor cells in women with deep endometriosis |
| Grantee: | Carina Calixto Jank |
| Support Opportunities: | Scholarships in Brazil - Master |