Evaluation of the effects of protein module supplementation on postprandial blood glucose in adults with type 1 diabetes mellitus

Author(s)

Loiane Sartori Oliveira

• Document type: Master's Dissertation
• Press: Ribeirão Preto.
• Institution: Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC)
• Defense date: 2019-11-13

Examining board members

Anderson Marliere Navarro; Telma Maria Braga Costa; Patricia Moreira Gomes

• Advisor: Anderson Marliere Navarro

Abstract

INTRODUCTION: Type 1 Diabetes mellitus (T1DM) is a chronic disease characterized by partial or total destruction of pancreatic beta-cells of the islets of Langerhans, resulting in the progressive inability to produce insulin. One of the most aggravating symptoms of T1DM is hypoglycemia, which can affect up to 90% of people treated with insulin. Combining this issue with dietary factors, recent studies have investigated the effects of protein supplementation on nocturnal hypoglycemic events. OBJECTIVE: Analyze the effect of postprandial blood glucose case ingestion on adults with type 1 diabetes mellitus.MATERIALS AND METHODS: Patients were recruited mainly from the Diabetic Endocrinology Outpatient Clinic (END) of the Ribeirão Preto Clinical Hospital - HCRP. The volunteers were continuously monitored for blood glucose using the Freestyle Libre (Abbott) flash monitoring, which they used for 14 days.Interventions took place at night, at 22h, and were divided into Experiments, with EC1 and EC2 as Control Experiments, in which there was no supplementation, and in Protein Experiment (EPTN) and Carbohydrate Experiment (ECHO), in which there was supplementation, casein and glucose, respectively.RESULTS: The average amount of casein offered to volunteers was 36.35g and glucose was 20.28g. After analysis of glycemic responses, it was observed that 64% of volunteers had hypoglycemia in EPTN, followed by 50% of volunteers in ECHO, and these Experiments had the lowest mean glycemic values, especially in the late period (3 to 5 hours after ingestion of supplements).CONCLUSION: In view of this, with the average amount of casein offered in this study, it cannot be stated that this protein alone increases glycemia in the late period, and consequently, its benefit regarding nocturnal hypoglycemia cannot be confirmed. (AU)

• FAPESP's process: 17/09271-8 - "evaluation of the effects of supplementation of protein module in late PRANDIAL glycemia in adults with diabetes mellitus type 1"
• Grantee: Loiane Sartori Oliveira
• Support Opportunities: Scholarships in Brazil - Master