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| Author(s): |
Carina Solon Silva
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas |
| Defense date: | 2011-04-02 |
| Examining board members: |
Licio Augusto Velloso;
Eduarado Rochete Ropelle;
Silvana Chiavegatto
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| Advisor: | Licio Augusto Velloso |
| Abstract | |
In the last decades, the obesity prevalence have a expressive increase in the world, been one of the most important actual phenomenon clinical-epidemiological. The high caloric intake and decrease of energy expenditure, associated with genetics factors play a relevant role in this disease. Taurine (Tau) is known to modulate a number of metabolic parameters such as insulin secretion and action and blood cholesterol levels. Recent data have suggested that Tau can also reduce body adiposity in C. elegans and in rodents. Since body adiposity is mostly regulated by insulin-responsive hypothalamic neurons involved in the control of feeding and thermogenesis, we hypothesized that some of the activity of Tau in the control of body fat would be exerted through a direct action in rat hypothalamus. Here, we show that the intracerebroventricular injection of an acute dose of Tau reduces food intake and activates signal transduction through the Akt/FOXO1, JAK2/STAT3 and mTOR/AMPK/ACC signaling pathways. These effects are accompanied by the modulation of expression of NPY. In addition, Tau can enhance the anorexigenic action of insulin. Thus, the aminoacid, Tau, exerts a potent anorexigenic action in the hypothalamus and enhances the effect of insulin on the control of food intake (AU) | |