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| Author(s): |
Regiane Mathias
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) |
| Defense date: | 2005-01-21 |
| Examining board members: |
Hiro Goto;
Heitor Franco de Andrade Junior;
Maria de Lourdes Higuchi;
Idercio Luiz Sinhorini;
Dewton de Moraes Vasconcelos
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| Advisor: | Hiro Goto |
| Abstract | |
Pathogenesis of tissue lesions in visceral leishmaniasis (VL) was searched in hamsters infected with Leishmania (Leishmania) chagasi amastigotes. Internalization of IgG from VL hamsters by human umbilical vein endothelial cells was observed in vitro and in liver and kidney in hamsters VL, under transmission electron microscopy, at 30 and 60 days of infection. Increased vascular permeability was observed at 60 days of infection in VL hamsters, and purified IgG from VL hamsters induced permeability increase in normal hamsters. These data suggest the internalization of IgG by endothelial cells as an alternative mechanism involved in the pathogenesis of tissue lesions in VL. (AU) | |