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| Author(s): |
Mara Junqueira Carneiro
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas |
| Defense date: | 2021-05-12 |
| Examining board members: |
Alexandra Christine Helena Frankland Sawaya;
Fernanda das Neves Costa;
Marcia Ortiz Mayo Marques;
Ana Lucia Tasca Gois Ruiz;
Paulo César Pires Rosa
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| Advisor: | Alexandra Christine Helena Frankland Sawaya |
| Abstract | |
"Schinus terebinthifolius" Raddi is a native species from South America, widely distributed in Brazil. It is popularly known as Brazilian peppertree, red pepper, Christmas berry and pink pepper. It has been used for a long time as a medicinal plant due to its anti-inflammatory, wound healing, antibacterial and antifungal activity. The aim of this study was to analyze the chemical composition and biological activities of the ethanolic extracts (EE) and essential oil (OE) of leaf, flowers and fruits of S. terebinthifolius. In addition to comparing the chemical composition of leaf extracts collected over a year. The chemical composition of EE was analyzed by LC-MS and its compounds identified as gallic acid, methyl gallate, ethyl gallate, sucrose and shikimic acid. The fractionation of EE by counter-current chromatography resulted in purified fractions. The major compounds of these fractions were analyzed by nuclear magnetic resonance and identified as: masticadienoic acid, 6- (8', 11'-heptadecadienyl)-salicylic acid and 6- (8'-heptadecenyl)-salicylic acid. Leaf extracts collected over the year from the same individual showed no marked difference in their chemical profile. However, some difference in the chemical profile was observed among the individuals, which could be explained mainly by the genetic variability and sex of individual. Each individual of Brazilian peppertree had a characteristic chemical profile. This may be related to the genetic variability and gender of the individual. Throughout the year, these extracts showed practically no chemical variations, except for one individual. The EE showed antibacterial potential against different strains of Gram-positive bacteria and high antioxidant potential by both the DPPH and ORACFL methods. The OE extracted from leaves, flowers and fruits of Brazilian peppertree showed chemical profiles with qualitative and quantitative differences. The flowers OE had the most complex composition hence showed the best results in terms of antibacterial and antioxidant activity. The results found in this study corroborate with those described in the literature regarding the therapeutic potential of S. terebinthifolius, with the possibility of using leaves, flowers and fruits, which have antimicrobial and antioxidant activities (AU) | |
| FAPESP's process: | 16/11524-9 - Chemical composition and biological activities of ethanolic extracts and essential oils of Schinus terebinthifolius Raddi |
| Grantee: | Mara Junqueira Carneiro |
| Support Opportunities: | Scholarships in Brazil - Doctorate |