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| Author(s): |
Marcelo Gomes Pereira
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) |
| Defense date: | 2009-05-06 |
| Examining board members: |
Patricia Chakur Brum;
Fabiana de Sant'Anna Evangelista;
Tais Tinucci
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| Advisor: | Patricia Chakur Brum |
| Abstract | |
The effects of aerobic exercise training on the cardiac renin-angiotensin system (RAS) was evaluated in mice with heart failure (HF) and control (WT). The exercise training was realized in a motor treadmill (8 weeks, 5d/wk, 60 min/day). The exercise tolerance, structural and function analysis were evaluated. Mice displayed cardiac dysfunction and fibrosis associated to increased in cardiac angiotensin II expression and angiotensin converting enzyme activity (ACE). The exercise training reduced cardiac angiotensin II and ACE levels to age-matched WT. In addition, increased the ACE2 expression, prevent the exercise intolerance and cardiac dysfunction, with little impact on cardiac remodeling (AU) | |