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| Author(s): |
Lidiane Zito Grund
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-12-02 |
| Examining board members: |
Carla Lima da Silva;
Maisa Splendore Della Casa;
Mônica Valdyrce dos Anjos Lopes Ferreira;
Olga Célia Martinez Ibañez;
Ana Flavia Popi
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| Advisor: | Carla Lima da Silva |
| Abstract | |
Thalassophryne nattereri fish venom induces the formation of a protective immune response characterized by memory B cells (Bmem) and the long-lived antibody-secreting cells (ASC). From a combined in vivo and in vitro approaches, we investigated the participation of memory T lymphocytes and CD4 or CD28 signaling molecules on the differentiation and maintenance of ASC survival and analyzed the hierarchical relationship between the two types of memory B cells. We demonstrated that ASC require dependent by localization (inflamed tissue, spleen or bone marrow) or B220 expression the integration of different cognate signals (BCR, TcM and TeM lymphocytes, CD4 or CD28 signaling) or soluble (IL-17A and IL-23) to survival and amplification of the memory antibodies production. (AU) | |