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| Author(s): |
Wilson Alves Ferreira Junior
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2010-12-17 |
| Examining board members: |
Yara Cury;
Edson Antunes;
Gisele Picolo
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| Advisor: | Yara Cury |
| Abstract | |
Animal toxins are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the signaling pathways of pain and its control. Sea anemone venoms contain many biologically active compounds such as cytolysins (1820 kDa) and ion channel modulators (35 kDa). In addition, low molecular weight compounds have been isolated and identified in these venoms; however few studies have been carried out in order to determine the biological activity of such compounds. BDS 391 is a low molecular weight and non-peptidic compound purified from the Brazilian sea anemone Bunodosoma cangicum venom. Studies on the structure of BDS 391 have demonstrated that this compound is composed of a bromoindole group connected to histidine. Our recent data have indicated that BDS 391 administered by intraplantar route into the rat hind paw induces potent peripheral analgesia in models of acute and chronic pain. These study can to contribute to the better characterization of the pain pathway and your control. (AU) | |
| FAPESP's process: | 08/01988-1 - Characterization of the molecular action of Bunodosine 391, an analgesic compound isolated from the venom of sea anemone Bunodosoma cangicum |
| Grantee: | Wilson Alves Ferreira Júnior |
| Support Opportunities: | Scholarships in Brazil - Master |