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| Author(s): |
Maria de Fatima Silva Montassier
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2008-05-27 |
| Examining board members: |
Leonardo José Richtzenhain;
João Pessoa Araujo Junior;
Magali D'Angelo;
Charlotte Marianna Harsi;
Dolores Ursula Mehnert
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| Advisor: | Leonardo José Richtzenhain |
| Abstract | |
Fifteen Brazilian field isolates of infectious bronchitis virus (IBV); were recovered, between 1988 and 2000, from commercial broiler or layer flocks located in South and Southeast Brazilian regions. Molecular and phylogenetic analysis of partial sequences of 5\'-proximal of S1 gene and 3\'-terminus of N gene from these IBV isolates, identified two main groups; the Massachusetts group and a Brazilian indigenous group, which presenting a high diversity regarding the first group or other IBV strains from different countries and continents. The major polymorphic sites are arranged in clusters and predominate in the regions of S1 and N genes which code for relevant structural and antigenic sites responsible for the expression of important biological properties. (AU) | |