Advanced search
Start date
Betweenand


Effects of HPV infection on TLR signaling pathway

Full text
Author(s):
Mirian Galliote Morale
Total Authors: 1
Document type: Doctoral Thesis
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ)
Defense date:
Examining board members:
Luisa Lina Villa; Erico Tosoni Costa; Luis Carlos de Souza Ferreira; Eloiza Helena Tajara da Silva; Mari Cleide Sogayar
Advisor: Luisa Lina Villa; Enrique Mario Boccardo Pierulivo
Abstract

Previous studies have shown that E6 and E7 HPV oncoproteins are involved in innate immune system dysregulation, causing alterations on Toll-like receptors (TLR) expression. Considering TLR pathway function, it would be advantageous for a virus to manipulate the response of this pathway so it can persist in cells without being detected by the immune system or to modulate this response to create a better environment for persistence of infection. However, many of the mechanisms leading to HPV infection clearance or persistence are still unknown and matter of active investigation. We analyzed in cervical cancer cell lines expression of genes from TLR pathway; several were differentially expressed between tumor cells lines and normal keratinocytes, including TLR adaptors molecules and genes associated with MAP kinase pathway, NFkappaB activation and antiviral immune response. About 90% of these genes were down regulated. Among them, we selected HMGB1 for further characterization due to its interference with tumor cell viability and proliferation. Altogether, our data indicate that high risk HPV E6 and E7 can inhibit TLR signaling pathway (AU)

FAPESP's process: 11/14416-9 - Study of E6 and E7 proteins from HPV16 and HPV6 and its effects on Toll like receptors signaling pathways
Grantee:Mirian Galliote Morale
Support Opportunities: Scholarships in Brazil - Doctorate