Proteins related to Toll Like Receptors signaling on HPV tumorigenesis

• Grant number: 16/25139-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: April 01, 2017
• End date: September 30, 2020
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Luisa Lina Villa
• Grantee: Mirian Galliote Morale
• Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Persistent infection of high-risk HPV is an essential factor for cervical cancer development. In woman with chronic infection, immune responses are inefficient and incapable to clear viral infection, leading to its persistence and an increased risk of tumor onset.Toll Like Receptors are a family of membrane receptors of the innate immune response, responsible for patterns of pathogens and danger signals recognition. TLR and NF-ºB signaling pathways have already been associated to several types of cancer and autoimmune diseases; but which the roles of these pathways are during HPV infection and how they can contribute to cervical cancer development it is not clear.During my PhD, I identified several proteins related to TLR pathway differentially expressed between cervical tumor cell lines and normal human keratinocytes. In particular, three proteins were found with high levels in cervical cancer cells, TLR4, SARM1 and HMGB1. The identified proteins, however, require further studies to determine their role in HPV-triggered tumorigenesis and its potential as biomarkers or as targets for chemotherapies. Therefore, in the present study we aimed to determine the importance of these alterations on tumors caused by HPV infection. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIMABUCO, FERNANDO MOREIRA; TAMURA, RODRIGO ESAKI; BETIM PAVAN, ISADORA CAROLINA; MORALE, MIRIAN GALLIOTE; VENTURA, ARMANDO MORAIS. Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses. GENETICS AND MOLECULAR BIOLOGY, v. 44, n. 1, 1, 2021. (19/15619-2, 16/25139-0, 18/08391-2, 18/14818-9, 20/05346-6)

MORALE, MIRIAN GALLIOTE; TAMURA, RODRIGO ESAKI; CINTRA, RICARDO; ARAUJO, NATALIA MENESES; VILLA, LUISA LINA. TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line. SCIENTIFIC REPORTS, v. 12, n. 1, p. 12-pg., 2022-04-25. (16/25139-0, 19/15619-2, 08/57889-1, 08/03232-1)

MORALE, MIRIAN GALLIOTE; TAMURA, RODRIGO ESAKI; SANCHEZ RUBIO, ILEANA GABRIELA. Metformin and Cancer Hallmarks: Molecular Mechanisms in Thyroid, Prostate and Head and Neck Cancer Models. BIOMOLECULES, v. 12, n. 3, p. 18-pg., 2022-03-01. (16/25139-0, 19/15619-2, 20/08271-7)

SIMABUCO, FERNANDO MOREIRA; TAMURA, RODRIGO ESAKI; BETIM PAVAN, ISADORA CAROLINA; MORALE, MIRIAN GALLIOTE; VENTURA, ARMANDO MORAIS. Molecular mechanisms and pharmacological interventions in the replication cycle of human coronaviruses. GENETICS AND MOLECULAR BIOLOGY, v. 44, n. 1, p. 18-pg., 2021-01-01. (16/25139-0, 19/15619-2, 18/14818-9, 20/05346-6, 18/08391-2)