Identification and functional annotation of novel transcripts with altered expression in pancreatic cancer

Author(s)

Omar Julio Sosa

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Matemática e Estatística (IME/SBI)
• Defense date: 2019-02-27

Examining board members

Eduardo Moraes Rego Reis; Helena Paula Brentani; Edna Teruko Kimura; Ana Cristina Victorino Krepischi; Israel Tojal da Silva

• Advisor: Eduardo Moraes Rego Reis; João Carlos Setubal

Abstract

In the present work, we applied a bioinformatic pipeline to process and analyse data from total RNA-seq strand-oriented generated in our laboratory from matched samples of tumor and non-tumor adjacent pancreatic tissue from 14 patients with the goal of generate a high resolution catalog of the composition and the alterations in the transcriptome of PDAC, including protein coding and non coding genes. (AU)

• FAPESP's process: 13/13350-0 - Implementation of computational analyses to identify novel biomarkers for molecular diagnosis of pancreatic tumors using next generation sequencing data
• Grantee: Omar Julio Sosa
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)