Evaluation of the osseointegration of implants with hydrophilic surfaces in rats with systemic involvement

Author(s)

Felipe Eduardo Pinotti

• Document type: Doctoral Thesis
• Press: Araraquara. 2021-10-06.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara
• Defense date: 2021-09-24
• Advisor: Rosemary Adriana Chiérici Marcantonio

Abstract

The aim of this study was to evaluate the effect of a surface modified by sandblasting and acid etching and kept in isotonic solution (Hydrophilic Surface) in comparison to a machined surface on the osseointegration of implants in animals with systemic involvement. 128 rats were used and divided into 2 studies. In the first study, 64 rats were used, which will be divided into 4 groups and evaluated in two experimental periods (15 and 45 days), with 8 animals in each group (n=8). The groups were divided according to the type of implant that was installed in the animals' tibia and their systemic condition: Hydrophilic/Healthy Group (HS); Hydrophilic/Diabetic Group (HD); Machined/Healthy Group (US); Machined/Diabetic Group (UD); In the second study, 64 rats were used, which were divided into 4 groups, and which were evaluated in two experimental periods (15 and 45 days), with n=8. The groups were divided according to the type of implant that was installed in the animals' tibia and their systemic condition: HS Group, Hydrophilic/Nicotine Group (HN), US Group and Machined/Nicotine Group (UN). In both studies, analyzes were performed: biomechanical, histometric, and microtomography. In the first study, is was found that implants with a hydrophilic urface had higher removal torque, amount of bone around the implants and higher values of %BIC and %BBT in normal and hyperglycemic animals. In the second study animals submitted to nicotine administration showed better levels of osseointegration when used implants with a hydrophilic surface than a machined surface. It is concluded that implants with a hydrophilic surface accelerate osseointegration in animals with systemic involvement. (AU)

• FAPESP's process: 18/01610-0 - Evaluation of osseointegration of ACQUA implants in rats with systemic involvement
• Grantee: Felipe Eduardo Pinotti
• Support Opportunities: Scholarships in Brazil - Doctorate