Influence of corticosterone in diferents doses in gerbil (Meriones unguiculatus) ventral prostate

Author(s)

Julia Quilles Antoniassi

• Document type: Master's Dissertation
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia
• Defense date: 2015-03-27

Examining board members

Sebastião Roberto Taboga; Luciana Bolsoni Lourenço; Luis Antonio Justulin Junior

• Advisor: Ricardo Alexandre Fochi; Sebastião Roberto Taboga

Abstract

The prostate, gland of reproductive system, has embryonic origin from the urogenital sinus and consists four lobes that are strongly associated with the urethra: anterior lobe or coagulating gland (CG), dorsal lobe (LD), dorsolateral lobe (LDL) and ventral lobe (LV). Steroid hormones, mainly androgens and estrogens, regulate the prostate physiology. While androgens induce differentiation, development and secretory activity, estrogens appear to modulate androgen effects, maintaining normal growth and prostate physiology. Although cortisol is widely used in drugs because their anti-inflammatory and immunosuppressive actions, little is known about the side effects of these drugs, especially in the prostate morphophysiology. Furthermore, it is known that this hormone is highly correlated with stress and some behavioral disorders. Thus, this research aimed evaluate, by histological methods, histochemical, immunocytochemical with structural and qualitative and quantitative parameters, various morphological and functional aspects of the ventral prostate gland of male gerbil (Meriones unguiculatus) after application of corticosterona. This hormone was applicated for five days with two doses of corticosterone: 0.5mg/kg/day and 1.5mg/kg/day, in addition, the groups were divided into a group with a 5-day period of rest after the treatment and another group was killed one day after the end treatment. The data showed that corticosterone has antiproliferative and anti-apoptotic properties on the prostate gerbils. This hormone also changed the frequency of AR, ER?, ER? e GR. We observed a reduction of glucocorticoids receptors expression when serum concentration of corticosterone was elevated. These changes led to the emergence of important prostatic dysplasia. There was a variation in effects triggered by this hormone in accordance with the applied dose, being that a higher dose reported effects more discrete and a lower dose was shown to be more impactful. The effects of corticosterone on nuclear receptors have been reversed or attenuated after rest period, which was not observed for apoptosis and cell proliferation patterns (AU)

• FAPESP's process: 13/13459-1 - Influence of different doses of corticosterone on the prostate of gerbil (Meriones unguiculatus)
• Grantee: Julia Quilles Antoniassi
• Support Opportunities: Scholarships in Brazil - Master