Full text
| |
| Author(s): |
Daniel Bueno Block
Total Authors: 1
|
| Document type: | Master's Dissertation |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas |
| Defense date: | 2013-09-20 |
| Examining board members: |
Jose Antonio Rocha Gontijo;
Rodrigo Ramos Catharino;
Elaine de Oliveira
|
| Advisor: | Jose Antonio Rocha Gontijo; Flávia Fernandes Mesquita |
| Abstract | |
Prior study about developmental plasticity hypothesis suggests that various adverse intra-uterine exposures lead to persistent fetal developmental adaptations. Maternal smoking is a very important modifiable adverse fetal exposure in western countries and leads to a decrease in the offspring's birth weight. Thus far, the specific adverse fetal smoking exposures and mechanisms underlying these associations on renal development and functional disorder are unclear. The present study investigates, in adult male rats, the effect of smoking exposure (Sk) in utero on blood pressure (BP), and its association with nephron structure and function changes. In the current study, showed in 13-week old Sk offspring enhanced arterial blood pressure, reduced nephron number are associated with higher TGF-?1 glomerular expression. Sk glomeruli also presented an upregulated collagen and fibronectin deposition intrinsically related to fibrotic process as compared to age-matched control group. From our present knowledge, these are the first data showing renal morphological and functional modifications in the gestational smoking model of fetal programming. The fetal-programmed adult rats showed structural kidney disorders associated with a striking stage of fibrosis, which led us to state that the glomerular overflow and subsequently TGF-?1 activity inducing fibrotic protein expression that may cause glomerular EMT (AU) | |
| FAPESP's process: | 11/17016-1 - Smoking in pregnant rats: effect on renal ontogenesis and angiogenesis in offspring. |
| Grantee: | Daniel Bueno Block |
| Support Opportunities: | Scholarships in Brazil - Master |