The environment in which we live has great influence on the fetal development and in adult life of the offspring. The food and smoking, as habits and lifestyle, that are directly associated to fetal organogenesis and ontogenesis disorders. Smoking is one of the factors of greatest concern to health authorities mainly due the health problems cause by cigarettes including in pregnant women. Several studies dealing with the harmful effects of cigarette in the pregnant women and in the development of the fetus, such as hypertension, vascular diseases, heart ischemia, miscarriage, morbidity, fetal growth retardation, among others. Inhalation of carbon monoxide by pregnant, through the cigarette, cause a state of hypoxia on fetus that may modify the organ development. In response to decreased fetal plasma oxygen level some pathophysiological changes may be observed, such as: increasing endogenous hormone erythropoietin (EPO) that regulates the tissue oxygenation, inducing erythropoiesis. The hypoxia inducible factor (HIF 1) acts regulating EPO production and angiogenesis and, the cell viability and proliferation among other functions. Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia stimuli could be the most important mediator of renal vascular development, mainly of glomerular vascular system. Taking in account these findings, this work aims to analyze the effect of smoking on ontogeny and renal vascular formation correlating these presumable findings to the expression of EPO, HIF-1 and VEGF, renal morphological and functional aspects and arterial blood pressure in pregnant rat's offspring.Keywords: Smoking, Renal Function, Pregnancy.
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