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Smoking in pregnant rats: effect on renal ontogenesis and angiogenesis in offspring.

Grant number: 11/17016-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Jose Antonio Rocha Gontijo
Grantee:Daniel Bueno Block
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The environment in which we live has great influence on the fetal development and in adult life of the offspring. The food and smoking, as habits and lifestyle, that are directly associated to fetal organogenesis and ontogenesis disorders. Smoking is one of the factors of greatest concern to health authorities mainly due the health problems cause by cigarettes including in pregnant women. Several studies dealing with the harmful effects of cigarette in the pregnant women and in the development of the fetus, such as hypertension, vascular diseases, heart ischemia, miscarriage, morbidity, fetal growth retardation, among others. Inhalation of carbon monoxide by pregnant, through the cigarette, cause a state of hypoxia on fetus that may modify the organ development. In response to decreased fetal plasma oxygen level some pathophysiological changes may be observed, such as: increasing endogenous hormone erythropoietin (EPO) that regulates the tissue oxygenation, inducing erythropoiesis. The hypoxia inducible factor (HIF 1) acts regulating EPO production and angiogenesis and, the cell viability and proliferation among other functions. Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia stimuli could be the most important mediator of renal vascular development, mainly of glomerular vascular system. Taking in account these findings, this work aims to analyze the effect of smoking on ontogeny and renal vascular formation correlating these presumable findings to the expression of EPO, HIF-1 and VEGF, renal morphological and functional aspects and arterial blood pressure in pregnant rat's offspring.Keywords: Smoking, Renal Function, Pregnancy.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BLOCK, DANIEL B.; MESQUITA, FLAVIA F.; DE LIMA, IZE P.; BOER, PATRICIA A.; GONTIJO, JOSE A. R.. Fetal Kidney Programming by Maternal Smoking Exposure: Effects on Kidney Structure, Blood Pressure and Urinary Sodium Excretion in Adult Offspring. NEPHRON, v. 129, n. 4, p. 283-292, . (11/17016-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BLOCK, Daniel Bueno. Smoking pregnant rats: involvement of hypoxia-inducible factor (HIF-1alpha), vascular endothelial growth factor (VEGF) and erythropoietin (EPO) on ontogenesis and renal function of the male offspring rats. 2013. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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