Nanomateriais ambientalmente amigáveis de alto desempenho para embalagens ativas e engenharia de tecido ósseo

Author(s)

Filipe Vargas Ferreira

• Document type: Doctoral Thesis
• Press: Campinas, SP.
• Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química
• Defense date: 2020-12-01

Examining board members

Liliane Maria Ferrareso Lona; Angela Maria Moraes; Rubens Maciel Filho; Luiz Henrique Capparelli Mattoso; Luiz Antonio Pessan

• Advisor: Rubia Figueredo Gouveia; Liliane Maria Ferrareso Lona

Abstract

The development of environmentally friendly materials for different sectors needs to be considered to ensure the sustainable development of our planet. In this thesis, we developed two high-performance biodegradable polymer materials to be used as active packaging and in regenerative medicine, i.e. sectors where the non-biodegradable polymers are widely used and recycling is not recommended as some active compounds or drugs are not removed during the process. (i) Functionalized cellulose nanocrystals (CNCs) isolated from sugarcane bagasse residue were assembled into poly(butylene adipate-co-terephthalate) - PBAT by casting. This method allowed the formation of a three-dimensional percolating network that interweaved the CNCs inside the polymer, modulating thermal and mechanical properties in a flexible material that cannot be synthesized with other manufacturing approaches. To achieve an antibacterial activity, the CNC/PBAT nanocomposite films were covered with silver thin film by magnetron sputtering. The proposed versatile material endowed with advanced functionalities revealed its potential for remarkably innovative approaches, including biodegradable active packaging. (ii) Highly interconnected, three-dimensional, light, and not toxic cellulose nanofibers-based cryogels containing bioactive glass (BG 45S5®) particles were synthesized to be used in bone tissue engineering. The material prepared by a new, scalable, environmentally-friendly, and facile method, optimally combined morphology and mechanical features and facilitated hydroxyapatite formation, while releasing essential ions to stimulate bone differentiation. Whereas the porous, rough features favored several cell functions, the ions were found to be critical to enhance the production of the bone morphogenetic protein from cells within the fractured area, thus accelerating the in vivo bone repair. Systemic biocompatibility indicated no negative effects on vital organs such as the liver and kidneys. Together, the results demonstrated the potential of this new green biomaterial for bone regeneration, which may be used as implants for the treatment of in vivo bone defects (AU)

• FAPESP's process: 16/09588-9 - Functionalization of cellulose nanocrystals to developing biodegradable nanocomposites PBAT/CNC
• Grantee: Filipe Vargas Ferreira
• Support Opportunities: Scholarships in Brazil - Doctorate