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| Author(s): |
Júlia Zago Castelli
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Campinas, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia |
| Defense date: | 2022-02-10 |
| Examining board members: |
Helena Coutinho Franco de Oliveira;
Carlos Henrique Grossi Sponton;
Sabrina Grassiolli
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| Advisor: | Helena Fonseca Raposo; Helena Coutinho Franco de Oliveira |
| Abstract | |
Plasma cholesteryl ester transfer protein (CETP) reduces HDL-cholesterol plasma levels and thus may enhance the atherosclerosis risk. We have recently identified that CETP expression has a novel function of reducing body adiposity. Under standard conditions (22 °C), CETP expressing mice are leaner and show increased lipolysis, brown adipose tissue (BAT) activity and whole-body energy expenditure compared to non-transgenic (NTg) littermates. The aim of this study was to evaluate how CETP mice modulate their body metabolism and composition during cold exposure (4°C) and thermoneutrality (30°C). Leaner CETP mice were able to maintain their body temperature during acute and chronic cold exposure due to their higher capacity to increase BAT related metabolic rates (VO2) compared with NTg mice. In addition, under thermoneutrality (when BAT activity is reduced), CETP mice exibited higher body temperature, food ingestion, body energy expenditure (light period) and reduced fed glycemia. These findings suggest that other tissues such as muscle, may account for the higher metabolic rates in CETP mice during thermoneutrality. Thus, we may conclude that CETP expression confers a greater capacity of elevating body metabolic rates during cold and thermoneutrality, what explains a leaner phenotype. Thus, this CETP effect has the potential to combat metabolic disorders (AU) | |
| FAPESP's process: | 19/02340-0 - The impact of cholesteryl ester transfer protein (CETP) expression on adiposity in thermoneutral condition and obesogenic diet: focus on white adipose tissue |
| Grantee: | Júlia Zago Castelli |
| Support Opportunities: | Scholarships in Brazil - Master |