Pralidoxime as antidote in the intoxication of rats with the insecticide metamidophos
Full text
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| Author(s): |
Regina Paes dos Santos
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) |
| Defense date: | 2002-03-26 |
| Examining board members: |
Maria José Cavaliere;
Edenilson Eduardo Calore;
Sérgio Colacioppo
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| Advisor: | Maria José Cavaliere |
| Abstract | |
The present investigation aimed the protection afforded by a single administration of pralidoxime preventing the muscle necrosis induced by the organophosphate compound metamidophos at different times after administration. We quantified the percentage of necrotic fibers of the diaphragm muscle in histological slices of animals that received pralidoxime at different times after administration, i.e. 0, 1, 3, 6 and 12 hours and of the animals that received only the insecticide. Pralidoxime administration protected metamidophos-induced muscle necrosis in all groups studied except in the 12 hours group. The earlier the administration of pralidoxime is given the greater is done the protection against muscle necrosis. This protection was not accompanied by complete reactivation of plasma cholinesterase activity. The time difference between plasma cholinesterase activity recover and muscle necrosis protection indicates that this method is not completely reliable for a patient follow-up, because some improvement may occur in spite of the low plasma cholinesterase activity. (AU) | |